Key result
Induction chemotherapy in pediatric ALL is linked to increased oxidative stress and early apoptosis.
Why the study?
The impact of oxidative stress and apoptosis at diagnosis on outcome after induction chemotherapy in childhood ALL was not well characterized.
Does chemotherapy induction alter oxidative stress and apoptosis levels in newly diagnosed children with acute lymphoblastic leukemia?
Observational (n=50)
Does chemotherapy induction alter oxidative stress and apoptosis levels in newly diagnosed children with acute lymphoblastic leukemia?
Induction chemotherapy in childhood acute lymphoblastic leukemia is associated with increased oxidative stress and elevated apoptosis indices early in treatment.
Oxidative stress and apoptosis markers may associate with induction outcomes in childhood ALL; hypothesis-generating and should not yet change practice.
This study aimed to evaluate oxidative stress and apoptosis in childhood acute lymphoblastic leukemia (ALL) at diagnosis and their impact on outcome at the end of the induction phase. Our study included 50 newly diagnosed children with ALL. Evaluation of oxidative stresses (malondialdehyde and total anti-oxidant capacity) was made at diagnosis and at the end of the induction phase. Apoptosis level was determined by fluorometric terminal deoxynucleotidyl transferase dUTP nick end labeling system for patients at diagnosis and after 1 week of treatment. Our study showed that there was increased oxidative stress at diagnosis and after treatment with chemotherapy. Apoptosis index was higher after 1 week of treatment with chemotherapy when compared to its level at diagnosis.
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Al-Tonbary et al. (2011) conducted an observational in childhood acute lymphoblastic leukemia (ALL) (n=50). Chemotherapy (induction phase) vs. Baseline (at diagnosis) was evaluated on Oxidative stress (malondialdehyde and total anti-oxidant capacity) and apoptosis level. Chemotherapy induction in childhood acute lymphoblastic leukemia was associated with increased oxidative stress and a higher apoptosis index after 1 week of treatment compared to baseline.
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