Key result
Maintenance haemodialysis in ESRD is linked to impaired lung function, with ~63% showing restrictive features.
Why the study?
End-stage renal disease causes multiple pulmonary complications and lung functions are decreased in ESRD patients undergoing maintenance haemodialysis.
Does end-stage renal disease with maintenance haemodialysis impair lung function parameters compared to healthy controls?
Cross-Sectional (n=60)
No
Does end-stage renal disease with maintenance haemodialysis impair lung function parameters compared to healthy controls?
ESRD patients undergoing maintenance hemodialysis exhibit significantly reduced pulmonary function, predominantly characterized by restrictive or mixed restrictive-obstructive patterns.
Background: End-stage renal disease causes multiple pulmonary complications and lung functions are decreased in ESRD patients undergoing maintenance haemodialysis. Objectives: To observe FVC, FEV1, FEV1/FVC ratio and FEF25-75% in ESRD patients undergoing maintenance haemodialysis to evaluate their lung functions status. Methods: This cross sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from July 2011 to June 2012. For this, 30 ESRD patients aged 25-55 years undergoing maintenance haemodialysis with less than 1 year duration were studied and 30 age, sex matched healthy subjects were taken as control. Patients were selected from the Nephrology department of BSMMU, Dhaka. FVC, FEV1, FEV1/FVC ratio and FEF25-75% were measured by a Digital Spirometer. For statistical analysis Independent Samplet test and One way ANOVA test were performed as applicable. Results: The mean percentage of predicted values of FVC, FEV1 and FEF25-75% were significantly lower in patients except FEV1/FVC ratio which was almost similar to control. 63.33% patients had restrictive and 36.67% patients had both restrictive and obstructive (small airway obstruction) feature. Conclusion: This study concluded that some pulmonary functions were markedly reduced in ESRD patients undergoing maintenance haemodialysis. In addition most of the patients were suffering from restrictive and some of them were affected with both obstructive and restrictive type of pulmonary disorders. DOI: http://dx.doi.org/10.3329/jbsp.v8i1.16645 J Bangladesh Soc Physiol. 2013, June; 8(1): 33-36
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Hoque et al. (2013) conducted a cross-sectional in End-stage renal disease (ESRD) (n=60). End-stage renal disease on maintenance haemodialysis vs. Healthy subjects was evaluated on FVC, FEV1, FEV1/FVC ratio and FEF25-75%. ESRD patients undergoing maintenance haemodialysis had significantly lower FVC, FEV1, and FEF25-75% compared to healthy controls, with 63.33% of patients exhibiting restrictive features.
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