Key result
Elevated BNP linked to ~2.6-fold higher odds of frailty in elderly adults without CVD.
Why the study?
The associations of B-type natriuretic peptide (BNP) with physical frailty status and each frailty domain in a general elderly population were unclear.
Is elevated BNP associated with physical frailty in an elderly population without cardiovascular disease?
Cross-Sectional (n=1,338)
Yes
Is elevated BNP associated with physical frailty in an elderly population without cardiovascular disease?
Odds Ratio: 2.63 (95% CI 1.61–4.32)
Elevated BNP levels are associated with a higher prevalence of physical frailty and pre-frailty in elderly individuals without known cardiovascular disease.
BNP-frailty links in community elders without CVD are hypothesis-generating; leaves open causal direction and any screening role.
OBJECTIVES: To explore the associations of B-type natriuretic peptide (BNP) with physical frailty status as well as each domain of frailty in a general elderly population. DESIGN: Cross-sectional analysis of prospective cohort study. SETTING: All of 31 communities in Jiang'an township. PARTICIPANTS: Overall 1338 participants (aged 70-89 years, mean 77.42±4.08 years) without a history of cardiovascular diseases in the third-wave of the aging arm of the Rugao Longevity and Aging Study (RuLAS). MEASUREMENTS: Frailty was defined as the presence of ≥3 domains among five modified Fried's criteria (unintentional weight loss, low physical activity level, weakness (low grip strength), exhaustion, and slowness (slow gait speed)) and pre-frailty as the presence of 1-2 domains. RESULTS: The prevalence of frailty and pre-frailty was 10.4% and 53.3%, respectively, in this elderly population. Elevated BNP (≥100 pg/mL) was significantly associated with pre-frailty (OR: 1.61, 95% CI: 1.13-2.29) and frailty (OR: 2.63, 95% CI: 1.61-4.32) after adjustment for covariates. In addition, elevated BNP was associated with low grip strength (OR: 2.00, 95% CI: 1.41-2.82) and low gait speed (OR: 1.62, 95% CI: 1.15-2.28) after adjustment for multiple covariates. Log BNP was inversely associated with grip strength (r= -0.265, p<0.001) and gait speed (r= -0.189, p<0.001). CONCLUSION: Elevated plasma BNP was associated with increased risks of frailty, pre-frailty, and low levels of grip strength and gait speed in the elderly community people.
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Yao et al. (2018) conducted a cross-sectional in Frailty (n=1,338). Elevated B-type natriuretic peptide (BNP) (≥100 pg/mL) vs. Non-elevated BNP (<100 pg/mL) was evaluated on Frailty (presence of ≥3 domains among five modified Fried's criteria) (OR 2.63, 95% CI 1.61-4.32). Elevated B-type natriuretic peptide (≥100 pg/mL) was significantly associated with higher odds of frailty (OR 2.63; 95% CI 1.61-4.32) in elderly adults without a history of cardiovascular disease.
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