Design, Synthesis and Docking Studies of Novel 1, 2, 3-Triazolyl Phenylthiazole Analogs as Potent Anti-HIV-1 NNRT Inhibitors

In an attempt to design and synthesize a new class of anti-HIV-1 RTIs i.e., 4-(phenyl)-N,N-bis((1-phenyl- 1H-1,2,3-triazol-4-yl)methyl)thiazol-2-amine derivatives, substituted 2-amino-4-phenylthiazoles were alkylated with propargyl bromide to obtain dialkyne 2-amino-4-phenylthiazoles. This dialkyne 2-amino-4-phenylthiazole was reacted with aryl azides to generate small library of 15 compounds (4a-o) by click chemistry. The obtained derivatives were studied for as an anti-HIV-1 NNRT Inhibitors. All synthesized compounds of 1,2,3-triazolylphenylthiazole series were be docked into the non-nucleoside inhibitor binding pocket (NNIBP) of HIV-1 RT and highly inhibiting derivatives studied for in vitro anti-HIV-1 assay.