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Allergic Contact Dermatitis PhysiologyAllergic Contact Dermatitis (ACD) involves the penetration of an allergen through the skin surface where it acts as a hapten by binding to epidermal proteins and eliciting, a delayed Type IV hypersensitivity reaction 48 to 120 hours after exposure.This immunologic response involves the activation of Th1 cells with the subsequent release of cytokines resulting in the classic inflammatory reaction. Barrier Creams and EmollientsBarrier creams and emollients physically help decrease exposure to chemicals by decreasing the permeability and increasing hydration
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Esperanza C. Welsh (2014) studied this question.
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