Key result
The NO-synthase inhibitor L-NNA abolished the protective effects of short-term adaptation to hypoxia on stress-induced disorders in rats, suggesting NO plays a positive role in this protection.
Nitric oxide plays a positive role in mediating the protective effects of short-term adaptation to hypoxia against stress-induced disorders in a rat model.
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NO may mediate hypoxia adaptation's protection against stress in seizure-prone rats; leaves open any clinical cardiovascular translation.
The NO-synthase inhibitor L-NNA (2.5 mg/100 g) abolished the protective effects of short-term adaptation to hypoxia (1 h, 5000 m above sea level) on the development of stress-induced disorders on the model of acoustic stress in the Krushinskii-Molodkina rats genetically predisposed to audiogenic seizures. Using the electronic spine resonance method (ESR) we also demonstrated an increase in NO production during short-term hypoxia in the blood and spleen. The results suggest that NO plays a positive role in protective effects of short-term adaptation to hypoxia.
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Кузенков et al. (2010) studied Stress-induced disorders. NO-synthase inhibitor L-NNA and short-term adaptation to hypoxia was evaluated on Development of stress-induced disorders and NO production. The NO-synthase inhibitor L-NNA abolished the protective effects of short-term adaptation to hypoxia on stress-induced disorders in rats, suggesting NO plays a positive role in this protection.
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