Identification and assessment of novel dynamic biomarkers for monitoring non‐traumatic osteonecrosis of the femoral head staging

This is the authors' abstract. We don't add key points for this paper.

Dear Editor, How to differentially diagnose non-traumatic osteonecrosis of the femoral head (NONFH) patients during the transition from early to late stage accurately and identify the core regulators governing such a critical transition may be one of the clinical problems that urgently needed to be solved. Studies have revealed that the initiation and development of NONFH are intricately regulated by a transcriptional regulatory network.1,2 To explore dynamic biomarkers to monitor NONFH staging, we herein divided NONFH patients into three stages according to radiological staging system, extensively collected their clinical symptoms, and formed a network fusion-based analysis by combing the NONFH-related