A Chromosome Region for Gamma2a and Beta2A Globulin H Chain Isoantigens in the Mouse

In the mouse, two gamma globulin isoantigens (allotypes, groups) controlled by alleles of a single gene locus have been reported (Kelus and Moor-Jankowski, 1961; Wunderlich and Herzenberg, 1963; Dubiski and Cinader, 1963; Dray, Lieberman, and Hoffman, 1963). We will show here that this locus is actually highly polymorphic (multi-allelic) and that the allele products are serologically cross-reacting. The cross reactions of the γ-globulins determined by the various alleles have shown that this locus is complex, and thus is reminiscent of the Gm and Rh loci in man and the H-2 locus in the mouse (Steinberg, 1962; Race and Sanger, 1958; Stimpfling and Snell, 1962). We will also describe a second locus specifying isoantigens of β2A-globulins and show that this locus is genetically closely linked to the first locus.