Synthesis of Thieno[2,3-d]pyrimidine Analogues of the Potent Antitumor Agent N-{4-[2-(2-Amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic Acid (LY231514)

Several thieno[2,3-dlpyrimidine analogues of the potent antitumor agent N-{4-[2-(2-amino-4(3~-oxo-7&pyrrolo[2,3-~pyrimidin-5-yl)e~yl]benzoylj-L-glutamic acid (LY231514,7) have been prepared by two different strategies.The fust involved S-alkylation of the 6-mercaptopyrimidines ( 13) and ( 14) with the a-haloketone (12), followed by cyclization to the thieno-