Efficacy of Amorphous Calcium Phosphate (ACP) Containing Adhesive in Preventing Demineralization during Orthodontic Treatment, a Triple Blinded Randomized Clinical Trial (RCT)

AIM: effects of an amorphous calcium phosphate (ACP) containing adhesive in reducing enamel demineralization during the early stage of fixed orthodontic treatment. MATERIALS AND METHODS: A triple blinded randomized clinical trial (RCT) was conducted to evaluate enamel demineralization on 255 anterior teeth in 23 patients over a period of 6 months. A split-mouth design was used; half of the anterior teeth were bonded with the ACP containing adhesive and the contralateral teeth received regular adhesive as a control. The enamel demineralization measurements were done at three different time intervals: immediately after bonding (T0), 1 month after bonding (T1), and 6 months after bonding (T2) using the DIAGNOdent device. The ACP containing adhesive showed significantly lower enamel demineralization than control adhesive. CONCLUSION: The result of this study suggests a positive effect on the reduction of enamel demineralization when using ACP containing adhesives during orthodontic treatment over regular adhesive.