Key result
The Triglyceride and Glucose index accurately predicted Non-Alcoholic Fatty Liver Disease with an area under the curve of 0.916, where a cut-off of 8.85 provided 93.5% sensitivity and 79% specificity.
Why the study?
Is the Triglyceride and Glucose Index (TyG) a reliable biomarker to predict Non-Alcoholic Fatty Liver Disease?
Cross-Sectional (n=124)
No
Is the Triglyceride and Glucose Index (TyG) a reliable biomarker to predict Non-Alcoholic Fatty Liver Disease?
Answers are grounded in this paper and cite their sources.
The TyG index is a fast, effective, and reliable biomarker for diagnosing NAFLD, with high sensitivity and specificity.
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of NAFLD in later life. This cross sectional study was aimed to evaluate the effectiveness of triglyceride and glucose index (TyG) as a possible biomarker of NAFLD. The study was conducted at the Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2019 to February 2020. A total of 124 subjects were taken as study population following selection criteria. Among them 62 were diagnosed patients of NAFLD and 62 were healthy subjects as control group. Fasting plasma glucose was measured by glucose oxidase method and serum triglyceride was measured by enzymatic-colorimetric method, while TyG index was calculated accordingly. The mean age was 39.5 ± 11.27 years in NAFLD patients and 37.10 ± 12.28 years in control subjects with male female ratio 1:1.7 and 1:1.8 respectively. Major portion of NAFLD patients (62.9%) were overweight (BMI ≥ 25). The mean fasting plasma glucose level was 5.73 ± 1.47 mmol/L in NAFLD patients and 5.27 ± 0.69 mmol/L in control group (p < 0.027). The mean serum triglyceride level was 237.19 ± 96.47 mg/dl in NAFLD patients and 117.32 ± 53.07 mg/dl in control group (p < 0.001). The triglyceride and glucose index (TyG) was 9.36 ± 0.47 in NAFLD group and 8.53 ± 0.42 in control group. TyG index was significantly higher in NAFLD patients in comparison to control group (p < 0.001). In ROC analysis, cut off value of TyG index was 8.85 with sensitivity 93.5% and specificity 79%. As a fast and effective method, TyG index can be used as a diagnostic tool to predict NAFLD.
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Hossain et al. (2020) conducted a cross-sectional in Non-Alcoholic Fatty Liver Disease (NAFLD) (n=124). Triglyceride and Glucose Index (TyG) vs. Healthy controls was evaluated on Diagnostic accuracy of TyG index for NAFLD (Area Under the Curve) (AUC 0.916, 95% CI 0.868-0.964, p=<0.001). The Triglyceride and Glucose index accurately predicted Non-Alcoholic Fatty Liver Disease with an area under the curve of 0.916, where a cut-off of 8.85 provided 93.5% sensitivity and 79% specificity.
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