Carter and Hubert (1984, Biometrics 40, 699-706) propose and apply an approach based on multivariate growth-curve theory to quantal bioassay over time. Their experimental data are reanalyzed using a fairly standard approach based on models for grouped response time data. This alternate approach is considerably more direct and theoretically more satisfactory. Practical advantages include direct assessment of model adequacy and parsimonious modelling of extra-multinomial variation.
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Petkau et al. (1989) studied this question.
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