Three new dimeric imidazole alkaloids with a methylene bridge, camellimidazole A–C ( 1 – 3 ), were isolated from Keemum black tea. Their structures were completely elucidated by a combination of diverse spectroscopic and single-crystal X-ray diffraction analyses. The plausible formation pathway of camellimidazole A–C was proposed. Compounds 1 and 2 exhibited remarkable protection against H 2 O 2 -induced neuronal damage at the concentration of 1.0 μM.
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Wang et al. (2018) studied this question.
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