From weak knees to a troubled heart - a case of severe autonomic dysfunction in Guillain-Barré syndrome

Adriana Pacheco; José Beato Coelho; Raquel Ferreira; Ana Briosa

doi:10.33678/cor.2025.017

September 1, 2025Cor et VasaOpen Access

From weak knees to a troubled heart - a case of severe autonomic dysfunction in Guillain-Barré syndrome

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Key Points

To describe a case of Guillain-Barré syndrome complicated by profound cardiovascular autonomic dysfunction mimicking acute coronary syndrome.
Clinical case report of a 67-year-old male presenting with progressive lower limb weakness following an upper respiratory tract infection.
Diagnostic workup included electrocardiography, cardiac troponin testing, coronary angiography, echocardiography, cerebrospinal fluid analysis, and neurological evaluation.
Treatment comprised intravenous immunoglobulin along with intensive supportive care.
The patient developed tetraparesis, respiratory failure, acute pulmonary edema, elevated troponin, and ischemic ECG changes, while coronary angiography showed no obstructive coronary artery disease.
Echocardiography revealed transient left ventricular dysfunction that fully resolved over time, alongside partial neurological recovery despite a prolonged course complicated by nosocomial infections.

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Implication

Case report reveals severe cardiovascular autonomic dysfunction mimicking acute coronary syndrome in Guillain-Barré syndrome, highlighting the need for vigilant cardiac monitoring.

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Pacheco et al. (2025) studied this question.

synapsesocial.com/papers/6ab3494868ccf8a57fcb588d https://doi.org/10.33678/cor.2025.017

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From weak knees to a troubled heart - a case of severe autonomic dysfunction in Guillain-Barré syndrome

Key Points

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Abstract

Discussion

Cite This Study

From weak knees to a troubled heart - a case of severe autonomic dysfunction in Guillain-Barré syndrome

Key Points

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Implication

Abstract

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Cite This Study

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