Hypothermia was produced in dogs by circulating, oxygenating and refrigerating venous blood in a small, plastic pump-oxygenator. The by-passed, contracting, hypothermic heart could be safely deprived of coronary flow for 15 minutes at 28°C and for at least 33 minutes at 20°C. During cardiac arrest induced by intracoronary injection of potassium citrate the safe period of myocardial ischemia could be prolonged to at least one hour at 20°C.
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Gollan et al. (1957) studied this question.