Key result
Inulin demonstrates high intra-subject variability, limiting its reliability for estimating extracellular volume in pregnancy.
Why the study?
The accuracy and reliability of inulin as a tracer for estimating extracellular fluid volume during pregnancy are uncertain due to observed large variations.
Does inulin reliably measure extracellular fluid volume in pregnant subjects?
Does inulin reliably measure extracellular fluid volume in pregnant subjects?
Inulin is not recommended as a tracer for measuring extracellular fluid volume in pregnancy due to large intra-subject variations.
Answers are grounded in this paper and cite their sources.
High intra-subject variability undermines inulin reliability for serial extracellular fluid volume estimates in pregnancy; leaves open validation of stable alternative tracers.
Summary Extracellular fluid volume estimated serially during pregnancy by inulin in seven subjects showed large variations from time to time in the same subject. Practical and theoretical objections are advanced to the use of inulin as a tracer in pregnancy.
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Robertson et al. (1970) studied this question. Inulin used to estimate extracellular fluid volume during pregnancy showed large intra-subject variations in seven subjects, raising practical and theoretical objections to its use.
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