A novel halogenating agent: A fungal halogenase Rdc2 from Pochonia chlamydosporia has been reconstituted in E. coli and biochemically characterized as the dedicated halogenase in radicicol biosynthesis. The enzyme displays broad substrate specificity towards molecules such as dihydroresorcylide (1) to generate mono- and dihalogenated (X=Br or Cl) derivatives, thus representing a promising biocatalyst for natural product biosynthesis.
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Zeng et al. (2010) studied this question.
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