The anti-thrombic activities of a 70% methanolic extract (CMe) from Cinnamomi Cortex on blood coagulation and fibrinolysis were investigated. CMe prevented the hepatic venous thrombosis in high butter diet-treated rats, and the decreases of blood platelets and fibrinogen in normal rats induced by endotoxin. CMe also inhibited the blood platelet aggregation induced by collagen, arachidonic acid and adenosine diphosphate (ADP) and the conversion of fibrinogen to fibrin induced by thrombin in in vitro experiments. Cinnamic aldehyde, a major. essential oily component of CMe were showed stronger inhibitory activity than that of CMe on the blood coagulation. These results suggest that Cinnamomi Cortex has anti-thrombic activities.
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Matsuda et al. (1987) studied this question.
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