NMR enantiodifferentiation studies are greatly improved by the simultaneous determination of accurate 1 H and 13 C chemical shift differences, even smaller than the NMR resonance line width, obtained from the analysis of highly resolved cross-peaks in spectral aliased pure shift (SAPS) HSQC spectra.
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Pérez‐Trujillo et al. (2014) studied this question.
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