Genetic disorders are diseases in which genetic factorsplay an important role in their etiology. They are classi-fied into chromosomal abnormalities,monogenic and mul-tifactorialdisorders.Whilechromosomalabnormalitiesandmonogenic disorders are purely genetic in nature,multifac-torialdisordersareproducedbytheinteractionbetweenen-vironmentalandgeneticfactors.Althoughmostgeneticdis-easesareindividuallyraretherearemanyof them.Thevastmajority are serious, none is curable and relatively few areamenabletosatisfactorytreatment.Anumberofsurveyshaveindicatedthatatleastoneineveryfiftynewbornshasama-jor congenital anomaly, one in hundred has a monogenicdisorderandoneintwohundredhasachromosomalabnor-mality.However,theprevalenceof geneticdisordersisquitevariable among different ethnic groups and across differentagegroups.Thecontrolanddeclineofenvironmentalcausesofchild-hoodmortalityinwesterncountriesthrewthegeneticcausesintogreaterprominence.Althoughthepicturemaybediffer-ent in third world countries, improvement in living condi-tionsiscausingasimilarshift.Themagnitudeof theimpactofgeneticdisordersonallsocietiesisquitesignificantneces-sitating their control which can be principally achieved byprevention.
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Hatem El‐Shanti (2001) studied this question.
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