Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

This is the authors' abstract. We don't add key points for this paper.

Taurine, an amino‐sulfonic acid mainly sourced from food, suppresses blood glucose by stimulating insulin secretion from pancreatic β‐cells. However, its relationship with glucagon‐like peptide‐1 (GLP‐1) secretion from enteroendocrine L cells is unclear. This study aimed to determine the role of taurine in GLP‐1 secretion from L cells. Taurine administration promoted GLP‐1 secretion in enteroendocrine L cell line GLUTag cells and increased plasma GLP‐1 in mice. Taurine uptake via the taurine transporter increased cytosolic ATP levels, resulting in higher intracellular Ca2+ concentrations and enhanced GLP‐1 secretion through ATP‐sensitive K+ channel closure. These findings may help identify new therapeutic targets for obesity and diet‐related disease prevention.