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August 1, 1997Antiviral chemistry & chemotherapyOpen Access

Structural Features and Anti-Human Immunodeficiency Virus (HIV) Activity of the Isomers of 1-(2′,6′-Difluorophenyl)-1H,3H-Thiazolo3,4-aBenzimidazole, a Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor

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Authors

ACAlba ChimirriUniversity of MessinaSGSilvana GrassoUniversity of CataniaCMC Molica

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Chimirri et al. (1997) studied this question.

synapsesocial.com/papers/6ab35011e8129fc9b332afe2https://doi.org/10.1177/095632029700800409
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  1. 1Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5“-(4”-amino-1“,2”- oxathiole-2“,2”-dioxide)] (TSAO) derivatives is determined by the mutation Glu138–>Lys on the p51 subunit.1994 · 90 citations
  2. 2HIV‐1‐specific RT inhibitors: Highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase1993 · 166 citations
  3. 3Non-nucleoside reverse transcriptase inhibitors (NNRTIs)1994 · 29 citations