Key result
Troponin T is detectable in ~48% of healthy term neonates, while troponin I is largely absent.
Why the study?
The concentrations and relationship of cardiac troponin I, troponin T, and creatine kinase MB in umbilical cord blood of healthy term neonates and their mothers at birth were not well characterized.
Cross-Sectional (n=85)
Cord blood troponin T is frequently detectable at birth in healthy term neonates, whereas troponin I is mostly undetectable, indicating these proteins are of neonatal origin and not influenced by maternal levels.
Detectable cord troponin T in healthy term neonates warrants interpretive caution; leaves open validation of neonatal-specific reference ranges.
Aims: To measure and compare cardiac troponin I, cardiac troponin T and creatine kinase MB concentrations in the umbilical cord blood of healthy term infants and to investigate the relationship between maternal and neonatal troponin values at birth. Methods: Troponin I, troponin T and creatine kinase MB concentrations were measured from the umbilical cord samples of 85 healthy term neonates and in the blood samples of their respective mothers at birth. Results: Median (interquartile range) umbilical cord concentrations were 0 μg/L (0–0) for troponin I, 0 μg/L (0–0.019) for troponin T and 4.90 μg/L (3.90–6.61) for creatine kinase MB. Troponin I and T concentrations were higher than the detection limit for the assay in 2 (2.3%) and 41 (48.2%) neonates, respectively. Two mothers (2.3%) had cTnT levels above the detection limit; none of them had increased levels of cTnI. Conclusion: Probably owing to differences in expression and assay detection limits, cord blood troponin T concentrations are frequently over the detection limit at birth, while troponin I is mostly undetectable and comparable with that in healthy pregnant women. These cardiac regulatory proteins are of neonatal origin and are not influenced by maternal levels.
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Trevisanuto et al. (2003) conducted a cross-sectional in Healthy term neonates (n=85). Maternal and neonatal cardiac biomarker concentrations was evaluated on Cardiac troponin I, troponin T and creatine kinase MB concentrations. Umbilical cord blood troponin T concentrations were above the detection limit in 48.2% of healthy term neonates, whereas troponin I was mostly undetectable (2.3%), independent of maternal levels.
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