Key result
ViViEchoformer deep learning model predicts LVEF from echocardiogram videos within ~6% mean error.
Why the study?
Accurate measurement of ejection fraction by echocardiogram is critical but limited by intra- and inter-observer variability in human interpretation.
Does the ViViEchoformer deep learning model accurately predict left ventricular ejection fraction from echocardiogram videos?
Does the ViViEchoformer deep learning model accurately predict left ventricular ejection fraction from echocardiogram videos?
Answers are grounded in this paper and cite their sources.
A novel video vision transformer deep learning model can accurately and automatically predict left ventricular ejection fraction directly from echocardiogram videos.
Heart disease is the leading cause of death worldwide, and cardiac function as measured by ejection fraction (EF) is an important determinant of outcomes, making accurate measurement a critical parameter in PT evaluation. Echocardiograms are commonly used for measuring EF, but human interpretation has limitations in terms of intra- and inter-observer (or reader) variance. Deep learning (DL) has driven a resurgence in machine learning, leading to advancements in medical applications. We introduce the ViViEchoformer DL approach, which uses a video vision transformer to directly regress the left ventricular function (LVEF) from echocardiogram videos. The study used a dataset of 10,030 apical-4-chamber echocardiography videos from patients at Stanford University Hospital. The model accurately captures spatial information and preserves inter-frame relationships by extracting spatiotemporal tokens from video input, allowing for accurate, fully automatic EF predictions that aid human assessment and analysis. The ViViEchoformer’s prediction of ejection fraction has a mean absolute error of 6.14%, a root mean squared error of 8.4%, a mean squared log error of 0.04, and an R² R 2 of 0.55. ViViEchoformer predicted heart failure with reduced ejection fraction (HFrEF) with an area under the curve of 0.83 and a classification accuracy of 87 using a standard threshold of less than 50% ejection fraction. Our video-based method provides precise left ventricular function quantification, offering a reliable alternative to human evaluation and establishing a fundamental basis for echocardiogram interpretation.
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Akan et al. (2024) studied Heart failure / Left ventricular ejection fraction estimation (n=10,030). ViViEchoformer (Deep learning video regressor) vs. Human interpretation (EchoNet dataset ground truth) was evaluated on Mean absolute error (MAE) of left ventricular ejection fraction prediction (MAE 6.14%). The ViViEchoformer deep learning model predicted left ventricular ejection fraction from echocardiogram videos with a mean absolute error of 6.14% and an R2 of 0.55.
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