Structural Assignment of the Peptide Antibiotic LP237-F8, a Metabolite of Tolypocladium geodes

This is the authors' abstract. We don't add key points for this paper.

Antibiotic LP237-F8 is the main cytotoxic metabolite isolated from the liquid cultures of the fungus Tolypocladium geodes. Complete 1 H and 13 C NMR resonance assignments and sequencing of the peptide was achieved by extensive high-field 2D NMR spectroscopy. The N- and C-terminals of LP237-F8 are protected with a capryloyl unit and the amino alcohol leucinol, respectively. This linear peptide is a new member of the peptaibol class of natural products, containing the unusual amino acids α-aminoisobutyric acid (Aib) and α-amino-α-ethyl- n -pentanoic acid (α-ethylnorvaline, α-EtNor).