Key result
Neonates undergoing surgery are at higher risk for anesthesia-related adverse events, and while animal studies suggest neurotoxicity, human evidence remains inconclusive.
Why the study?
Does anesthesia cause neurotoxic brain injury in neonates undergoing surgery?
Does anesthesia cause neurotoxic brain injury in neonates undergoing surgery?
This review highlights the unique physiologic challenges and potential neurotoxic risks of anesthesia in neonates.
Answers are grounded in this paper and cite their sources.
Neonatal anesthesia warrants continued caution without practice change; inconclusive human data leaves open neurotoxicity and requires prospective trials.
Neonates undergoing surgery are at higher risk than older children for anesthesia-related adverse events. During the perioperative period, the maintenance of optimal hemodynamics in these patients is challenging and requires a thorough understanding of neonatal physiology and pharmacology. Data from animals and human cohort studies have shown relation of the currently used anesthetics may associate with neurotoxic brain injury that lead to later neurodevelopmental impairment in the developing brain. In this review, the unique neonatal physiologic and pharmacologic features and anesthesia-related neurotoxicity will be discussed.
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Si Ra Bang (2015) conducted a review in Neonatal anesthesia and neurotoxicity. Anesthesia was evaluated. Neonates undergoing surgery are at higher risk for anesthesia-related adverse events, and while animal studies suggest neurotoxicity, human evidence remains inconclusive.
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