Key result
Promoter SNP rs4705343 in miR-143/145 is linked to increased susceptibility to conotruncal heart defects.
Why the study?
The association of functional polymorphisms in the promoter of miR-143/145 with susceptibility to conotruncal heart defects in the Chinese Han population was unclear.
Are SNPs rs353292 and rs4705343 in the promoter of miR-143/145 associated with susceptibility to conotruncal heart defects in a Chinese population?
Case-Control (n=562)
Are SNPs rs353292 and rs4705343 in the promoter of miR-143/145 associated with susceptibility to conotruncal heart defects in a Chinese population?
SNP rs4705343 in miR-143/145 is a potential genetic marker for conotruncal heart defects in the Chinese Han population.
Aim: Conotruncal heart defects (CTDs) are the most common form of congenital heart disease. We investigated the association of these two single-nucleotide polymorphisms (SNPs) in the promoter of miR-143/145 (rs353292 and rs4705343) with the susceptibility to CTDs in a Chinese population. Materials & methods: Two SNPs in the promoter of miR-143/145 (rs353292 and rs4705343) have been examined by PCR-RFLP methodology for 259 CTDs patients and 303 control subjects. Results: An association between SNP rs4705343 of miR-143/145 and CTDs has been confirmed in the Chinese Han population. Conclusion: Our results indicated that SNP rs4705343 in miR-143/145 is a potential genetic marker for CTDs in the Chinese Han population.
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Wen et al. (2019) conducted a case-control in Conotruncal heart defects (n=562). SNPs in the promoter of miR-143/145 (rs353292 and rs4705343) vs. Control subjects was evaluated on Susceptibility to conotruncal heart defects. SNP rs4705343 in the promoter of miR-143/145 was associated with susceptibility to conotruncal heart defects in a case-control study of 562 Chinese Han individuals.
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