Key result
Mitral stenosis represents the most common cardiac lesion in North China despite rare rheumatic fever.
Why the study?
Mitral stenosis is commonly associated with rheumatic fever in Western countries, but in North China, where rheumatic fever is almost unknown, mitral stenosis remains prevalent.
Observational (n=39)
No
Highlights the high prevalence of mitral stenosis in North China despite the near absence of typical rheumatic fever, challenging the exclusive etiologic link between the two conditions.
Challenges rheumatic fever as sole cause of mitral stenosis; leaves open nonrheumatic etiologies for prospective study.
Ever since the etiologic relationship between rheumatic fever and stenosis of the mitral valve was established half a century ago by Hayden,1Fagge,2and Duckworth,3these two conditions have been closely associated in the minds of European and American students of heart disease. It is interesting to discover, therefore, that in North China, where typical rheumatic fever is almost unknown, mitral stenosis is the most common heart lesion, and its incidence is comparable to that in western countries. Table 1 shows the prevalence of mitral stenosis in our records as compared with those of St. Bartholomew's Hospital, London, for 1913, and of the Johns Hopkins Hospital, Baltimore, for 1914. In contrast to this, Table 2 shows the relative incidence of rheumatic fever and infectious arthritis in the same hospitals. This paper deals with thirty-nine cases of mitral stenosis occurring in Chinese patients. These include all of the definitely diagnosed cases
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Henry Edmund Meleney (1924) conducted an observational in Mitral stenosis (n=39). Absence of rheumatic fever was evaluated. Mitral stenosis was found to be the most common heart lesion in North China, with an incidence comparable to western countries, despite typical rheumatic fever being almost unknown.
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