Key result
Corticosteroid therapy markedly improved muscle strength and activities of daily living in a patient with HTLV-1 associated demyelinating neuropathy who had failed prior intravenous immunoglobulin therapy.
Why the study?
Does corticosteroid therapy improve muscle strength in a patient with HTLV-1 associated demyelinating neuropathy?
Case Report (n=1)
No
Does corticosteroid therapy improve muscle strength in a patient with HTLV-1 associated demyelinating neuropathy?
Corticosteroid therapy may be more effective than IVIg for treating CIDP-like neuropathy in HTLV-1 infected patients.
Answers are grounded in this paper and cite their sources.
May support corticosteroids in refractory HTLV-1 neuropathy; hypothesis-generating pending controlled trials.
The patient was a 58-year-old man, who was hospitalized with progressive bilateral leg weakness, and sensory impairment in all four extremities. Chronic inflammatory demyelinating polyneuropathy (CIDP) was suspected based on an electrophysiological examination, and intravenous immunoglobulin therapy (IVIg) was initiated. However, his symptoms progressed. The serum and cerebrospinal fluid were positive for human T-lymphotropic virus type 1 (HTLV-1) antibodies; hence the patient was diagnosed as having HTLV-1 associated neuropathy. After administration of corticosteroid, muscle strength markedly improved. Thus, our findings suggest that rather than IVIg, corticosteroid therapy is recommended for the treatment of CIDP like neuropathy in HTLV-1 infected patients.
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Yamamoto et al. (2018) conducted a case report in HTLV-1 associated demyelinating neuropathy (n=1). Corticosteroid therapy vs. Intravenous immunoglobulin therapy (IVIg) was evaluated on Muscle strength and ADL improvement. Corticosteroid therapy markedly improved muscle strength and activities of daily living in a patient with HTLV-1 associated demyelinating neuropathy who had failed prior intravenous immunoglobulin therapy.
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