Key result
ACE inhibitors and ARBs attenuate isoproterenol-induced LV dysfunction and myocardial damage in canine models.
Why the study?
The potential of ACE inhibitors and ARBs to prevent isoproterenol-induced left ventricular dysfunction and myocardial damage in dogs was examined.
Do ACE inhibitors or ARBs prevent isoproterenol-induced left ventricular dysfunction and myocardial damage in dogs?
Do ACE inhibitors or ARBs prevent isoproterenol-induced left ventricular dysfunction and myocardial damage in dogs?
ACE inhibitors and ARBs protect against acute beta-adrenergic overstimulation-induced myocardial damage and LV dysfunction in a canine model.
Answers are grounded in this paper and cite their sources.
ACEI/ARB may attenuate ISO-induced LV dysfunction in dogs; leaves open translation to human cardiomyopathy.
We examined whether angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor blockers (ARB) prevent isoproterenol (ISO)-induced left ventricular (LV) dysfunction in dogs. The effects of a large dose of ISO, 1 microg/kg/min, 3 h infusion, were investigated in three groups with simultaneous infusion of an ACE inhibitor (quinaprilat), ARB (candesartan) or saline. ISO infusion significantly decreased LV dP/dt, LV ejection fraction and LV fractional shortening, and significantly increased tau, the time constant of isovolume relaxation of LV, and LV end diastolic pressure. All of these changes were significantly attenuated in both the ACE inhibitor and ARB groups, especially in the ARB group. Serum levels of creatinin kinase isoform MB, lactate dehydrogenase and lipid peroxide were significantly increased by ISO. However, the increases in these markers of myocardial damage were significantly diminished by simultaneous infusion of an ACE inhibitor or ARB, especially by ARB. In conclusion, an ACE inhibitor and ARB prevent LV systolic and diastolic dysfunction as well as myocardial damage induced by excess beta-adrenergic stimulation.
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Ohta et al. (2001) studied Isoproterenol-induced left ventricular dysfunction. ACE inhibitor (quinaprilat) or ARB (candesartan) vs. Saline was evaluated on Left ventricular systolic and diastolic function parameters and myocardial damage markers. Simultaneous infusion of an ACE inhibitor or ARB significantly attenuated isoproterenol-induced left ventricular systolic and diastolic dysfunction and myocardial damage in dogs.
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