Enhancing Prostate-Specific Antigen (PSA) Density Analysis Using Advanced OTFT Biosensor Technology

This paper explores the application of Organic Thin-Film Transistors (OTFTs) sensors in their detection of tumor cells, with a specific focus on measuring Prostate-Specific Antigen (PSA) concentration, a critical biomarker for diagnose of prostate-cancer. The study emphasizes the importance of sensitivity and specificity in the OTFT sensor’s compare to digital rectal examination (DRE) performance, as these parameters are essential for accurate cancer diagnostics. Sensitivity ensures that the sensor can detect low PSA concentrations, which is crucial for early-stage detection, while specificity minimizes false positives, distinguishing between malignant and benign conditions effectively. The input characteristics of the OTFT sensor, particularly the gate voltage, play a significant role in its ability to detect PSA. Proper calibration of the gate voltage enhances the sensor’s sensitivity, enabling the detection of subtle changes in PSA levels. The output-characteristics, represented by the drain current, provide a quantifiable measure of PSA concentration, which is essential for assessing the presence and progression of tumour cells. This study demonstrates the potential of OTFT sensors as a non-invasive, precise, and reliable method for early cancer detection. By optimizing sensitivity, specificity, and the sensor’s input–output characteristics, OTFT technology could significantly improve diagnostic accuracy and patient outcomes in cancer care.