The Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate Selectivity of Phosphodiesterases

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTThe Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate Selectivity of PhosphodiesterasesDavid T. Manallack, Richard A. Hughes, and Philip E. ThompsonView Author Information Victorian College of Pharmacy, Monash University (Parkville Campus), 381 Royal Parade, Parkville Victoria, 3052, Australia, and Department of Pharmacology, The University of Melbourne, Grattan Street, Victoria, 3010, Australia Cite this: J. Med. Chem. 2005, 48, 10, 3449–3462Publication Date (Web):April 9, 2005Publication History Received17 December 2004Published online9 April 2005Published inissue 1 May 2005https://pubs.acs.org/doi/10.1021/jm040217uhttps://doi.org/10.1021/jm040217ureview-articleACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views2047Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystal structure,Inhibitors,Monomers,Peptides and proteins,Selectivity Get e-Alerts