Key result
Focal freeze injury in adult chickens induced tissue-specific isoform transitions of myosin heavy chain and C-protein during skeletal muscle regeneration that qualitatively resemble developing muscles.
Population
Regenerating skeletal muscles (anterior latissimus dorsi and posterior latissimus dorsi) of adult chickens
Comparison
Focal freeze injury vs Control tissues (uninjured)
Design
Preclinical
Follow-up
2, 5, and 8 days
Authors
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Distinct MHC/C-protein isoform patterns emerge during avian muscle regeneration; leaves open translation to mammalian or human myopathies.
Isoform transitions in regenerating skeletal muscles resemble those in developing muscles, with tissue-specific patterns of gene expression.
Saad et al. (1987) studied Regenerating skeletal muscle. Focal freeze injury vs. Control tissues was evaluated on Expression of myosin heavy chain (MHC) and C-protein isoforms. Focal freeze injury in adult chickens induced tissue-specific isoform transitions of myosin heavy chain and C-protein during skeletal muscle regeneration that qualitatively resemble developing muscles.