Molecular correlates of anemia in primary myelofibrosis: a significant and independent association with U2AF1 mutations

Anemia is a cardinal manifestation of primary myelofibrosis (PMF) and constitutes a negative prognostic factor, being an independent risk factor for survival both in the international prognostic score system (IPSS) 1 and dynamic IPSS (DIPSS)-plus. 2 Anemia in myelofibrosis is also inversely correlated with patient-reported quality of life. Between 35 and 54% of patients with PMF are anemic at diagnosis with a hemoglobin level of <10 g/dl 1 with the proportion increasing to 47–64% after about 1 year from the time of diagnosis. 3