Key result
Asthma is linked to increased arterial stiffness vs. matched controls despite preserved endothelial function.
Why the study?
Patients with asthma have increased cardiovascular risk and systemic inflammation, but the relationship between systemic inflammation, vascular function, and arterial stiffness in asthma independent of physical activity and fitness is unknown.
Does asthma increase arterial stiffness and impair endothelial function compared to matched controls when controlling for physical activity and fitness?
Case-Control (n=32)
Does asthma increase arterial stiffness and impair endothelial function compared to matched controls when controlling for physical activity and fitness?
Asthma-related inflammation may elevate CVD risk; leaves open whether targeting IL-6 or CRP alters outcomes.
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Moore et al. (2015) conducted a case-control in Asthma (n=32). Asthma vs. Matched controls without asthma was evaluated on Vascular function (flow-mediated dilation) and arterial stiffness (pulse wave velocity). Patients with asthma had significantly higher arterial stiffness than matched controls without asthma, while endothelial function and systemic inflammation were similar between the two groups.
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