Bottromycin A2 is hydrolyzed to tetrapeptide and dipeptide by alkaline hydrolysis. The structures of both peptides are determined to be 3, 3-dimethyl-2-aminobutylylvalyl-3-methylprolylglycine and 3-methyl-3-phenylalanyl-3-(2-thiazolyl)-β-alanine. Hydrochloric acid hydrolysis of bottromycin A2 gives Δ1-isocaproyltetrapeptide and the structure is discussed on the bases of pKa studies. The structure of bottromycin A2 is proposed from the results above described.
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NAKAMURA et al. (1966) studied this question.