Key result
Post-mastectomy breast cancer linked to impaired autonomic function and heightened oxidative stress before radiotherapy.
Why the study?
Breast cancer survivors are at increased risk of cardiovascular complications due to autonomic dysfunction and oxidative stress, but the relationship with HRV, BRS, and biochemical markers is not well characterized.
Are heart rate variability, baroreceptor sensitivity, and biochemical markers altered in breast cancer patients post-mastectomy compared to healthy controls?
Case-Control
Are heart rate variability, baroreceptor sensitivity, and biochemical markers altered in breast cancer patients post-mastectomy compared to healthy controls?
Breast cancer patients post-mastectomy exhibit significant autonomic dysfunction and increased oxidative stress, which may predispose them to future cardiovascular events.
Answers are grounded in this paper and cite their sources.
May signal autonomic dysfunction in breast cancer survivors; leaves open whether HRV or BRS predicts events.
Background and Aim: The global burden of breast cancer is on the rise, not sparing countries undergoing rapid urbanization. India is one among the top emerging countries to be affected by this disease. Breast cancer survivors are at increased risk of developing cardiovascular complications due to autonomic dysfunction and oxidative stress. Changes in autonomic balance can be assessed by measuring resting heart rate variability (HRV) and baroreceptor sensitivity (BRS). Serum levels of malondialdehyde and inflammatory markers give an estimate of ongoing oxidative stress. Methods: A study was conducted in two groups: (i) study group consisted of women with breast cancer who have undergone modified radical mastectomy and awaiting radiotherapy and (ii) control group consisted of normal healthy age-matched volunteers. Resting HRV and BRS were measured for participants of both the groups. Estimation of serum oxidative stress markers and inflammatory markers was also done. Results: Decrease in HRV and BRS accompanied by increase in oxidative stress markers and inflammatory markers in circulation was observed in cancer patients when compared to control group. Conclusion: Autonomic dysfunction, high oxidative stress, and decreased BRS were prominent in breast cancer patients, which could expose them to future cardiovascular events.
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Nithiya et al. (2018) conducted a case-control in Breast cancer. Breast cancer vs. Normal healthy age-matched volunteers was evaluated on Resting heart rate variability (HRV), baroreceptor sensitivity (BRS), and serum oxidative stress and inflammatory markers. Breast cancer patients awaiting radiotherapy after mastectomy exhibited decreased heart rate variability and baroreceptor sensitivity, alongside increased oxidative stress and inflammatory markers.
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