Key result
Thrombolysis followed by LMWH successfully resolves severe PE and DVT in early pregnancy.
Case Report (n=1)
No
Thrombolytic treatment followed by low-molecular-weight heparin was successfully and safely used in an 8-week pregnant woman with severe pulmonary embolism and deep vein thrombosis, resulting in maternal recovery and a healthy full-term delivery.
Supports individualized thrombolysis for life-threatening PE in early pregnancy; leaves open need for prospective safety data.
A 29-year-old woman in her 8th week of pregnancy was referred to our hospital for swelling in the lower extremities, rapid onset of dyspnea (1 hr) and pre-syncope. Severe right ventricular dysfunction and moderate pulmonary hypertension were detected using 2-dimentional Doppler echocardiography. In addition, left calf vein and proximal thromboses were detected by venous compression ultrasound imaging. After successful thrombolytic treatment, the patient quickly recovered and was discharged from hospital on subcutaneous low-molecular-weight heparin. She delivered a normal, healthy infant at full-term (40 weeks). (Korean Circulation J 2007;37:130-133)
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Ha et al. (2007) conducted a case report in Deep Vein Thrombosis and Pulmonary Embolism (n=1). Thrombolytic treatment and subcutaneous low-molecular-weight heparin was evaluated on Clinical recovery and delivery outcome. Thrombolytic treatment followed by low-molecular-weight heparin successfully treated severe pulmonary embolism and deep vein thrombosis in an 8-week pregnant woman, leading to a normal full-term delivery.
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