Breast cancers are derived from the epithelial cells that line the terminal duct lobular unit.Cancer cells that remain within the basement membrane of the elements of the terminal duct lobular unit and the draining duct are classified as in situ or non-invasive.An invasive breast cancer is one in which there is dissemination of cancer cells outside the basement membrane of the ducts and lobules into the surrounding adjacent normal tissue.Both in situ and invasive cancers have characteristic patterns by which they can be classified.
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J R C Sainsbury (2000) studied this question.
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