Lithium acetate catalyzed aldol reaction between trimethylsilyl enolates and aldehydes in a DMF–H2O (50:1) solvent proceeded smoothly to afford the corresponding aldols in good to high yields. It is noted that trimethylsilyl enolates derived from carboxylic esters behaved as excellent nucleophiles in the above reaction.
No takes yet. Share an insight, caveat, or question.
Nakagawa et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: