Key result
Hypertrophic adult myocardium shows increased integrin-linked and zipper interacting protein kinase content at Z-lines.
Why the study?
The localization and content of myosin-activating protein kinases in human myocardium, including their changes in embryonic, normal adult, and hypertrophic hearts, were not well characterized.
Myosin-activating protein kinases are localized in sarcomere Z-lines and their increased content in hypertrophic myocardium suggests a role in human heart development and hypertrophy.
Z-line localization of myosin kinases in human myocardium leaves open their roles in sarcomere regulation; hypothesis-generating for hypertrophy mechanisms.
Using the immunofluorescence approach, we have determined that the recently detected protein kinases, among which are RhoA-activated kinase, integrin-linked kinase, zipper interacting protein kinase, and death-associated protein kinase, which are capable of phosphorylating myosin, are localized in the Z-lines sarcomeres of human myocardium. Additionally, we studied the content of integrin-linked and zipper interacting protein kinases in human embryonic myocardium, as well as in normal and hypertrophic adult human heart. The content of these protein kinases in adult normal myocardium increases in comparison with the embryonic heart. The content of integrin-linked and zipper interacting protein kinases in hypertrophic myocardium is higher compared with the normal adult heart. The data obtained suggest the involvement of these protein kinases in the development and hypertrophy of human heart.
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Степанова et al. (2008) studied Hypertrophic myocardium. Hypertrophic myocardium vs. Normal adult myocardium was evaluated on Content of integrin-linked and zipper interacting protein kinases. Integrin-linked and zipper interacting protein kinases are localized in sarcomere Z-lines, with increased content in hypertrophic adult human myocardium compared to normal adult hearts.
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