Key result
Proton beam therapy resulted in significant symptom improvement and radiologically stable disease at 1 year with minimal toxicity in a patient with unresectable neck osteosarcoma.
Why the study?
Does proton beam therapy improve symptoms and provide local control in a patient with unresectable osteosarcoma of the neck?
Case Report (n=1)
Does proton beam therapy improve symptoms and provide local control in a patient with unresectable osteosarcoma of the neck?
Proton beam therapy provided symptom relief and local control at 1 year in a case of unresectable neck osteosarcoma, though retrospective dosimetric comparison showed noninferiority of photon IMRT.
Supports palliative proton therapy in rare unresectable neck osteosarcoma; hypothesis-generating and leaves open advantage over IMRT.
A 33-year-old man with symptomatic, unresectable osteosarcoma of the neck experienced disease progression despite treatment with multiple systemic agents. Given the tumor location, adjacent to the spinal cord and encasing the brachial plexus, proton beam therapy was recommended instead of conventional photon radiation therapy. The treatment was delivered in 3 weekly 10 cobalt-gray equivalents fractions, and there was minimal associated toxicity. There has been significant improvement in the patient's presenting symptoms as well as radiologically stable disease at 1 year. A photon intensity-modulated radiation therapy plan was created retrospectively for dosimetric comparison and demonstrated noninferiority, thereby highlighting the need for judicious use of proton therapy in certain cases.
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Gutiontov et al. (2016) conducted a case report in Osteosarcoma of the neck (n=1). Proton beam therapy vs. Retrospective photon intensity-modulated radiation therapy plan was evaluated on Symptom improvement and radiologically stable disease. Proton beam therapy resulted in significant symptom improvement and radiologically stable disease at 1 year with minimal toxicity in a patient with unresectable neck osteosarcoma.
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