The present report shows that the simultaneous application of two biological response modifiers (recombinant human gamma-interferon plus recombinant human alpha-tumor necrosis factor) has a lethal effect on living laryngeal and salivary gland carcinomas. A cytostatic or cytotoxic effect of the two substances alone could only be observed in occasional cases. The results suggest a synergistic action of gamma-interferon and alpha-tumor necrosis factor that might be of therapeutic value for head and neck carcinomas in the future.
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Zenner et al. (2010) studied this question.