Electrochemical Organophosphate Sensor Based on Oxime Chemistry

We combined keto-oxime chemistry with cyanide potentiometry to build an electrochemical oxime-based organophosphate (OP) sensor. The sensor is based on a specific chemical reaction, and high chemical selectivity is demonstrated by the testing with the potential interferents. Low concentrations (ppm or lower) of acetic anhydride, a good OP chemical warfare agent simulant, and malathion, an OP pesticide, show a fast potential response of tens of mV or larger. The experimental conditions for the oxime-based electrochemical sensor are optimized in terms of the chemical structure of oxime and the solution pH.