Key result
Agonist-independent K+[ACh] currents are produced by an endogenous G protein primed by empty receptors, which can be blocked by Gi-3 alpha antibody or pertussis toxin.
Agonist-independent activation of atrial K+ channels is mediated by endogenous G proteins primed with GTP by empty receptors.
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May modulate basal atrial K+ conductance; leaves open relevance to human arrhythmias or targeted therapies.
Okabe et al. (1991) studied this question. Guanosine triphosphate (GTP) and G protein inhibitors vs. Absence of agonist/GTP was evaluated on Single channel currents in cell-attached or excised, inside-out membrane patches. Agonist-independent K+[ACh] currents are produced by an endogenous G protein primed by empty receptors, which can be blocked by Gi-3 alpha antibody or pertussis toxin.
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