A dynamic imine library formed in solution provides a fast route to drug discovery. Imine formation from diamine 4 and a sublibrary of aldehydes can be used for the efficient discovery of glycosidase inhibitors through a new combinatorial approach. When the equilibrium shown is reached rapidly under dilute conditions, a mixture of imines is produced and can be screened by the glycosidase, which binds preferentially to the best inhibitor.
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Gerber‐Lemaire et al. (2002) studied this question.