Concise and practical syntheses of (2S)‐R207910 (3a) and (2R)‐R207910 (3b) have been achieved in high overall yield of 12 % in 10 steps for each isomer starting from a known intermediate following Sharpless asymmetric epoxidation, regioselective epoxide opening, modified allylzinc bromide addition as key reactions.
No takes yet. Share an insight, caveat, or question.
Chandrasekhar et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: