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An examination of the complex oscillations and chaotic behavior observed in a model of the peroxidase-catalyzed oxidation of NADH is made via numerical simulation and a fast/slow variable analysis. The NADH is considered to be a slowly varying species, compared to oxygen and the two key free-radical intermediates in the mechanism. By considering NADH to be a parameter which modulates the dynamics of a reduced model composed of the remaining fast variables, the origin of the complex oscillations is elucidated. Possibilities for the origin of the observed chaotic behavior are also suggested by this approach. The observation of birhythmicity and metastable chaos in this system may also be related to the two inherent time scales in the kinetics.
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Larter et al. (1988) studied this question.
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