Key result
Elevated plasma D-dimer levels (≥0.8 μg/ml) were an independent risk factor for lethal outcome in patients with musculoskeletal sarcoma (HR 7.3).
Why the study?
Do elevated plasma d-dimer levels predict metastasis and lethal outcome in patients with musculoskeletal sarcoma?
Observational (n=85)
No
Do elevated plasma d-dimer levels predict metastasis and lethal outcome in patients with musculoskeletal sarcoma?
Hazard Ratio: 7.3 (95% CI 1.8–49)
Absolute Event Rate: 18.2% vs 4.9%
p-value: p=0.004
Elevated plasma d-dimer levels prior to intervention may serve as a prognostic marker for poor oncological outcomes in musculoskeletal sarcoma.
Elevated pre-treatment d-dimer was associated with higher metastasis and mortality risk; leaves open its added value for risk stratification in sarcoma.
BACKGROUND: Plasma d-dimer levels have been associated with the status of tumor progression or oncological outcomes in cancer. Although there are many evidences suggesting the involvement of procoagulant trend in musculoskeletal sarcoma, no clinical data on d-dimer levels and oncological outcome of musculoskeletal sarcoma has been reported. METHODS: In this study, we included a total of 85 patients who were diagnosed with musculoskeletal sarcoma and treated at our institute. Plasma d-dimer levels were determined before performing any clinical intervention, including open biopsy, chemotherapy, radiotherapy or tumor resection. We evaluated the effect of d-dimer levels and other clinicopathological factors on oncological outcomes of patients. RESULTS: Upregulation of plasma d-dimer levels proved to be an independent risk factor for metastasis and lethal outcome of patients with musculoskeletal sarcoma. CONCLUSIONS: Upregulation of plasma d-dimer levels were indicated poor oncological outcome in metastasis and total survival rate of musculoskeletal sarcoma patients. Hence d-dimer levels may be a helpful marker for evaluating the tumor progression status and prognosis of musculoskeletal sarcoma.
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Morii et al. (2011) conducted an observational in Musculoskeletal sarcoma (n=85). Elevated plasma D-dimer levels vs. Low plasma D-dimer levels was evaluated on Lethal outcome (HR 7.3, 95% CI 1.8-49, p=0.004). Elevated plasma D-dimer levels (≥0.8 μg/ml) were an independent risk factor for lethal outcome in patients with musculoskeletal sarcoma (HR 7.3).
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