Electrochemical studies of regorafenib in non-aqueous media

A novel tyrosine kinase inhibitor, regorafenib was electrochemically studied using a GC disc electrode in non-aqueous media. A well-resolved, irreversible, diffusion-controlled oxidation peak was obtained at 1.55 V in acetonitrile solution containing 0.1 M TBAClO4. Experimental conditions such as scan rate, indicate that two electrons play a role in the electrochemical oxidation of regorafenib. The recommended method was successfully applied to the determination of regorafenib in drug capsules.